Professor Movafagh: Medical Genetics
Code: 124
Presentation: Basic Sciences of Medicine, Clinical Preliminaries (According to Curriculum Approved by University)
Prerequisite: Cellular- Molecular Biochemistry, Cell Physiology
Type of Course: Theoretical (34 hours), Practical (- hours), Total (34 hours)
Total Goals: expecting in this course to have a good understanding of principal subjects of medical genetics, and recognize them in natural inheritance processes, common diseases and congenital disorders by knowing the most principal common techniques of medical and molecular genetics;
1- Strategic position of medical genetics in health system;
2- Types of inheritances and their similarities and differences, and also ability to distinguish them;
3- Important common human diseases in each inheritance discussed in medical genetics;
4- Types of congenital disorders, teratogens and twins, and their relation with medical genetics;
5- Application of the most important methods discussed in pre and post- birth genetic diagnosis;
6- Epigenetics and human diseases;
7- Cytogenetic and molecular genetics in human and their strong methods in diagnosis of human diseases;
8- Cellular and molecular fundamentals and origins of genetic diseases in human;
9- Principles of genetic consultation and its strategic position in determining risk and determining the disease inheritance pattern;
10- Strong methods of genetic engineering in medicine;
11- Strong methods of gene therapy and its important methods;
12- Strong methods of cancer genetics and important methods of its diagnosis and treatment;
13- Position of pharmacogenetics and individual medicine requirement;
14- Important genetic approaches and methods in prevention, recognition and treatment of diseases;
Description: introduction to the cellular and molecular genetics, types of inheritance patterns, role and application of genetic consultation in diagnosis of disease, determining the congenital pattern and risk, introduction to the strong cellular especially molecular methods in diagnosis and prevention of important genetic diseases, gene therapy, cancer genetics, epigenetics and pharmacogenetics;
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Necessary Content:
1- History, position, importance, applications of medical genetics and mission;
2- Clinical cytogenetic: necessary preliminaries, chromosome disorders methods;
3- Molecular genetics and gene mutations, importance and applications;
4- Function, gene expression, and its regulation;
5- Principles of genetic consultation, tree analysis and application in mono- gene diseases;
6- Mono-gene inheritance patterns in human diseases (Mendel inheritance);
7- Mono-gene inheritance patterns in human diseases (Holandric inheritance);
8- Multi-factorial, cytoplasm and immunity inheritances;
9- Congenital disorders, teratogens and twins;
10- Genetic engineering and its applications in medicine;
11- The recent developments in pre- and post- birth molecular diagnosis;
12- Epigenetics and human diseases;
13- Gene therapy in human, the most principal common methods by introducing the important samples;
14- Application of viral and non-viral vectors in gene therapy;
15- Cancer genetics, common methods of gene therapy in cancer as well as the important samples;
16- Pharmacogenetics and medicine based on the individual specifications (individualized medicine);
Remarks: a training course of clinical genetics may be randomly designed and held in the centers with necessary qualifications by confirmation of genetic boards and general medicine. In this case, medical genetic consultation may be held in workshop form.
Genetics is omitted from the basic sciences general exam and included in pre-internship general exam..